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Cross sensitivity and/or related problems: Patients who are hypersensitive to erythromycin or other macrolides may also be hypersensitive to clarithromycin.
Hepatic and renal function impairment: Clarithromycin is principally excreted by the liver. Therefore, caution should be exercised in administering the antibiotic to patients with impaired hepatic function. Caution should also be exercised when administering clarithromycin to patients with moderate to severe renal failure.
Use in Pregnancy: There are no adequate and well-controlled studies in pregnant women. Clarithromycin should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. (See WARNINGS.)
Use in Lactation: Clarithromycin and its active metabolite are distributed into human breast milk. Therefore, caution should be exercised when clarithromycin is administered to a nursing woman.
